Geminal dihalogen isosteric replacement in hydrated AI-2 affords potent quorum sensing modulators.
نویسندگان
چکیده
Hydrated carbonyl groups in AI-2, a quorum sensing autoinducer, make key hydrogen bonding interactions in the binding site of LsrR (a transcriptional regulator). This can be recapitulated with geminal dibromides, via halogen bonding. Geminal dihalogens represent interesting isosteric replacements for hydrated carbonyls in ligands and are currently under-utilized in ligand design.
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عنوان ژورنال:
- Chemical communications
دوره 51 13 شماره
صفحات -
تاریخ انتشار 2015